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In fact, patients taking Semaglutide experienced a 26% reduction in cardiovascular events compared to those on placebo

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As GLP-1Rs are expressed in multiple brain regions, and GLP-1RAs such as liraglutide and lixisenatide can penetrate the blood-brain barrier, liraglutide and exendin-4 can be vagus-dependent or independent in the suppression of the food intake (176)

But the TGA is currently considering bringing them down to a Schedule 8 classification the same category as THC-containing cannabinoid medicines so that means they could be used in controlled, clinical settings down the line